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Neonatal Med > Volume 25(4); 2018 > Article
Neonatal Medicine 2018;25(4):170-177.
DOI:    Published online November 30, 2018.
Comparison of Hemoglobin Correction Effects According to Storage Period and Other Factors in the Transfusion of Packed Red Blood Cells in Neonatal Intensive Care Unit Patients
Ji Hyun Park, Seom Gim Kong, Yoo Rha Hong
Department of Pediatrics, Kosin University College of Medicine, Busan, Korea
Corresponding author:  Yoo Rha Hong, Tel: +82-51-990-6278, Fax: +82-51-990-3338, 
Received: 17 September 2018   • Revised: 22 October 2018   • Accepted: 7 November 2018
Preterm infants frequently require red blood cell (RBC) transfusions in neonatal intensive care units (NICU). Storage RBCs undergo many changes during storage periods. We aimed to compare the hemoglobin (Hb) correction effect according to the period of RBC storage and investigate the factors influencing Hb correction.
This retrospective study reviewed the medical records of 289 patients who received RBC transfusion more than once in the NICU of Kosin University Gospel Hospital between February 2006 and March 2016. The subjects were classified into two storage groups: short-term (≤7 days, n=88) and long-term (>7 days, n=201), according to the period of RBC storage. We checked Hb levels by complete blood cell count tests conducted within 2 days before and 5 to 9 days after the first transfusion. We compared the Hb difference between the two groups and analyzed the factors influencing Hb correction.
Excluding the use of an invasive ventilator, there was no significant difference between the two groups in terms of clinical characteristics. There was no significant difference in the Hb correction effect between the two groups (P=0.537). Birth weight greater than 1,500 g, higher weight at transfusion, and larger volume of transfusion were significant prognostic factors affecting greater changes in Hb. In addition, surgery experience, higher Hb level at transfusion, and additional blood tests were found to be significantly associated with less changes in Hb.
The RBC storage period did not affect the Hb correction effect. The Hb correction effect may be diminished in infants with lower birth weight and lower weight at transfusion under unstable clinical conditions.
Key Words: Premature birth, Erythrocyte aging, Erythrocyte transfusion, Newborn infant, Hemoglobins


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