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Journal of the Korean Society of Neonatology 2010;17(1):84-93.
Published online May 1, 2010.
Risk Factors of Nosocomial Sepsis in Very Low Birth Weight Infants.
Cu Rie Kim, Seung Yeon Kim, Ho Jin Park, Mo Ran Ki, Hye Sun Yoon
1Department of Pediatrics, Eulji University School of Medicine, Seoul, Korea. yhs3211@eulji.ac.kr
2Department of Preventive Medicine, Eulji University School of Medicine, Seoul, Korea.
극소 저출생 체중아에서 병원 감염 패혈증의 위험인자
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This study was performed to estimate the incidence of nosocomial sepsis and to identify the most relevant risk factors for nosocomial sepsis in high-risk very low birth weight (VLBW) infants.
A retrospective review of 341 VLBW infants, admitted to the Neonatal Intensive Care Unit of the Eulji University Hospital (Daejeon & Seoul) between January 2002 and June 2009, who survived more than 72 hours was performed. The incidence, causative organisms, risk factors and prognosis of nosocomial sepsis in VLBW infants were analyzed.
The incidence of nosocomial sepsis was 16.1% and the onset date of nosocomial sepsis was 21.5+/-15.9 days (mean+/-SD) after delivery. Staphylococcus aureus (21.3%) was the most common organism in the patients with nosocomial sepsis in VLBW infants. The multiple logistic regression analysis showed that, gestational age [odds ratio (OR), 0.87; 95% CI, 0.83-0.91], umbilical artery catheter use for more than 5 days (OR, 2.2; 95% CI, 1.15-4.46), umbilical venous catheter use for more than 5 days (OR, 2.1; 95% CI, 1.11-4.16), peripheral arterial line use (OR, 2.1; 95% CI, 1.14-4.04) and intravenous intralipids (OR, 4.3; 95% CI, 1.13-14.32) were identified as risk factors.
The limited usage of intravascular catheter related procedures and the short providence of intravenous nutrition may decrease the incidence of nosocomial sepsis in VLBW infants.
Key Words: Nosocomial infection, Very low birth weight infant, Risk factor


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