The Risk Factors of Cholestasis in Very Low Birth Weight Infants.

Jeon,  Ga Won; Choi,  Chang Won; Hwang,  Jong Hee; Gu,  Su Hyun; Kim,  Yu Jin; Lee,  Jang Hoon; Chang,  Yun Sil; Park,  Won Soon

Original Article

Journal of the Korean Society of Neonatology 2005;12(1):63-69.
Published online May 1, 2005.

The Risk Factors of Cholestasis in Very Low Birth Weight Infants.

Ga Won Jeon, Chang Won Choi, Jong Hee Hwang, Su Hyun Gu, Yu Jin Kim, Jang Hoon Lee, Yun Sil Chang, Won Soon Park

¹Department of Pediatrics, Sungkyunkwan University, College of Medicine, Samsung Medical Center, Seoul, Korea. wspark@smc.samsung.co.kr
²Department of Pediatrics, Seoul National University, College of Medicine, Bundang Hospital, Seoul, Korea.
³Department of Pediatrics, Inje University, College of Medicine, Ilsan Paik Hospital, Seoul, Korea.

출생체중 1,500 g 미만의 극소 저출생체중아에서 담즙정체증 발병의 위험인자

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Abstract

PURPOSE
This study was aimed to investigate the risk factors of cholestasis in very low birth weight infants (VLBWI). METHODS: The study includes 466 VLBWI admitted to the neonatal intensive care unit at Samsung medical center from November 1994 to January 2003 and the data were collected retrospectively from their medical records. They were divided into two groups; cholestatic group (group 1) and control group (group 2) by level of direct bilirubin at 2.0 mg/dL. RESULTS: The mean gestational age and birth weight were lower in group 1. In group 1, enteral feeding was started later, time to achieve full and near full enteral feeding were delayed and duration of parenteral nutrition was longer than group 2. The incidence of bronchopulmonary dysplasia was significantly higher in group 1, but the incidences of sepsis and necrotizing enterocolitis were not different between the two groups. After adjusting for birth weight and gestational age, logistic regression analysis of the above factors revealed that the factors significantly related to cholestasis were longer duration of parenteral nutrition and longer time to achieve near full enteral feeding. CONCLUSION: Earlier near full enteral feeding and shorter duration of parenteral nutrition decreased the incidence of cholestasis.

Key Words: Cholestasis; Very low birth weight infant; Enteral feeding; Total parenteral nutrition