eISSN 2287-9803 
pISSN 2287-9412 
Aims and Scope
Ethical Guidelines
연구출판윤리규정
Editoral Board
Forthcomming Issue
Current Issue
Archive
Search
Most Read Articles
Informaion for Authors
e-Submission
Check List
Contact us
Original Article
  |   Neonatal Med_24_4_171_177.pdf
Neonatal Med November;24(4):171-177.
Published online 2017 November 30
Copyright ⓒ 2017 Neonatal Medicine Neonatal Medicine
Clinical Significance of Neonatal Lenticulostriate Vasculopathy: Association with Congenital Cytomegalovirus Infection
Kyungwon Park, Hyunsoo Kim, Sun Young Ko, Son Moon Shin, Yeon Kyung Lee, and Byung Hee Han*
Department of Pediatrics, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea
Department of Radiology*, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea
Corresponding Author: Yeon Kyung Lee , Tel: +82-2-2000-7771 , Fax: +82-2-2000-7789 , Email: ykleeped@hanmail.net
ABSTRACT
Purpose: To investigate clinical characteristics of neonates with lenticulostriate vasculopathy (LSV) and determine the correlation between LSV and clinical characteristics, especially congenital cytomegalovirus (CMV) infection. Methods: We retrospectively reviewed the medical records of neonates with LSV, born at Cheil General Hospital between January 2005 and December 2015. LSV was graded into three groups based on the number of the LSV lesions and classified into an isolated and combined group showing LSV with coexistent abnormalities noted on brain sonography. We compared clinical data based on the LSV classification. Results: Our study included 102 neonates with LSV, which showed an unilateral pattern in 10 and bilateral pattern in 92 neonates. The numbers of neonates studied based on LSV grading were 33, 53, and 16 in grade 1, 2, and 3, respectively. We observed the isolated LSV in 62 and the combined type in 40 neonates. We observed that 93 (91.2%) of the neonates with LSV did not show specific underlying cause for this condition. Congenital CMV infection was detected in 7 neonates, including 0, 5, and 2 neonates belonging to grade 1, 2, and 3, respectively. Among these, 2 neonates showed the isolated, and 5 showed the combined type of LSV. Statistically, congenital CMV infection was more significantly associated with LSV in grade 2 and 3 than in grade 1 (P<0.05). Additionally, congenital CMV infection was more commonly observed in the combined than in the isolated LSV type showing a marginal association (P=0.07). Conclusion: We observed that LSV was not clinically significant except when associated with CMV infection. We suggest that neonates presenting with a grade 2 or higher of LSV or a combined type of LSV detected via neonatal brain ultrasonography should be evaluated for CMV infection.
Keywords: Lenticulostriate vasculopathy, Cytomegalovirus, Neonate
Copyright(c) By Korean Society of Neonatology. All right reserved.
Rm.1207, King's garden 3 Block, 34, Sajik-ro 8-gil, Jongno-gu, Seoul 110-872, Korea. TEL: +82-2-730-1993 FAX: +82-2-730-1994 Email:neonate2002@hanmail.net