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Original Article
  |   Neonatal Med_24_4_178_181.pdf
Neonatal Med November;24(4):178-181.
Published online 2017 November 30
Copyright ⓒ 2017 Neonatal Medicine Neonatal Medicine
Association of Immunoglobulin G at Birth with Late-Onset Sepsis and Related Mortality in Very Low Birth Weight Infants
Hye Ri Yun, Jeong Min Shin, Young Mi Yoon, Jae Seok Shin, Ji Hyun Kim, Hannah Cho, Seung Han Shin, Ee-Kyung Kim, and Han-Suk Kim
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
Corresponding Author: Seung Han Shin , Tel: +82-2-2072-7230 , Fax: +82-2-2072-3917 , Email: revival421@snu.ac.kr
Purpose: We aimed to evaluate the association between immunoglobulin G (IgG) at birth and late-onset sepsis (LoS) in preterm infants. Methods: Medical records of very-low-birth-weight infants, born at gestational age <28 weeks, between 2013 and 2016, were retrospectively reviewed. Subjects were divided into two groups based on the occurrence of LoS (LoS vs. non-LoS), and IgG levels at 1 day, and at 2 weeks and 4 weeks after birth were investigated. IgG levels, other perinatal factors, and clinical factors were compared in the two groups. The relationship between IgG levels and mortality among infants in the LoS group was also analyzed. Results: A total of 105 infants were analyzed after exclusion of cases with early onset sepsis or death at <72 hours of life. Gestational age in the LoS group was lower than in the non-LoS group (25.0±1.8 vs. 26.3±1.4 weeks, P=0.004). IgG levels at birth were similar between the two groups (236.4±96.4 vs. 282.0±104.7 mg/dL, P=0.078). Multivariate analysis showed that IgG at birth was not an independent risk factor for LoS. In the LoS group, IgG levels at birth were comparable between survivors and cases involving mortality. Conclusion: IgG levels at birth were not associated with the occurrence of LoS in extremely preterm infants.
Keywords: Immunoglobulin G, Extremely preterm infant, Late-onset sepsis, Gestational age
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