Association between Respiratory Disorders and Candidate Genes in Korean Newborn Infants.

Jo,  Heui Seung

doi:2013.20.3.311

Neonatal Med > Volume 20(3); 2013 > Article

Review

Neonatal Medicine 2013;20(3):311-317.
DOI: https://doi.org/10.5385/nm.2013.20.3.311 Published online October 29, 2013.

Association between Respiratory Disorders and Candidate Genes in Korean Newborn Infants.

Heui Seung Jo

Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea. joneona@cha.ac.kr

Abstract

Respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) remain major acute and chronic postnatal lung diseases in the Neonatal Intensive Care Unit. RDS and BPD are multifactorial diseases influenced by genetic factors. Specific genetic variants contributing to the regulation of pulmonary development, structure and function or inflammatory response, and host defense mechanism can be risk factors for the development of RDS and/or BPD. This review summarizes recent association studies of genetic polymorphisms with RDS and BPD. In addition, we analyze the genetic differences among various study populations to identify potential candidate genes for susceptibility to RDS and BPD in Korean preterm infants.

Key Words: Gene polymorphism; Respiratory distress syndrome; Bronchopulmonary dysplasia; Premature newborn