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Journal of the Korean Society of Neonatology 2008;15(1):38-43.
Published online May 1, 2008.
Correlation of Cord Serum Adiponectin and IGF-I with Fetal Growth in Healthy Term Neonates.
Ji Young Kim, Su Jin Cho, Hae Soon Kim, Hye Sook Park, Eun Ae Park
1Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea. pea8639@ewha.ac.kr
2Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea.
제대혈 Adiponectin과 IGF-I이 태아성장에 미치는 영향
, , , ,
1
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Abstract
PURPOSE
The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth.
METHODS
Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72). The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI).
RESULTS
The mean cord serum APN was 29.2+/-10.46 microgram/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001). The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26+/-21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI.
CONCLUSION
APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight.
Key Words: Adiponectin, Insulin like growth factor-I, Fetal growth


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