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Journal of the Korean Society of Neonatology 2003;10(2):248-253.
Published online November 1, 2003.
Effect of Hyperbilirubinemia on the Brainstem Auditory Evoked Response in Newborn Piglets.
Chang Won Choi, Jong Hee Hwang, Saem Kang, Jae Won Shim, So Hee Chung, Sun Young Koh, Yun Sil Chang, Won Soon Park
1Department of Pediatrics, Samsung Seoul Hospital, College of Medicine, Sungkyunkwan University, Seoul, Korea. wspark@smc.samsung.co.kr
2Department of Pediatrics, Kangbuk Samsung Hospital, College of Medicine, Sungkyunkwan University, Seoul, Korea.
3Department of Pediatrics, Samsung Cheil Hospital, College of Medicine, Sungkyunkwan University, Seoul, Korea.
신생자돈에서 고빌리루빈혈증이 뇌간청각유발반응에 미치는 영향에 대한 연구
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Abstract
PURPOSE
We sought to know the effect of hyperbilirubinemia on brainstem auditory evoked response in newborn piglets.
METHODS
To achieve the concentration of bilirubin above 20 mg/dL, we injected a bolus of 50 mg/kg of bilirubin intravenously over 30 minutes, followed by 30-40 mg/kg/ hr of bilirubin continuous intravenous infusion to 10 newborn piglets. Brainstem auditory evoked responses were obtained from these piglets at baseline, 1 hour, 2 hours, 3 hours and 4 hours after the exposure to hyperbilirubinemia. RESULTS: The mean amplitude of wave V was 0.33+/-0.03 microV at baseline, 0.32+/-0.04 microV at 1 hour, 0.33+/-0.05 microV at 2 hours, 0.23+/-0.04 microV at 3 hours and 0.26+/-0.05 microV at 4 hours of experiment and began to decrease after 3 hours of the exposure to hyperbilirubinemia. The latency of wave III was 4.06+/-0.08 ms at baseline, 3.95+/-0.09 ms at 1 hour, 4.05+/-0.10 ms at 2 hours, 4.05+/-0.09 ms at 3 hours, 4.12+/-0.11 ms at 4 hours of experiment and began to increase after 1 hour of the exposure to hyperbilirubinemia.
CONCLUSION
Hyperbilirubinemia decreased the amplitude of wave V and increased the latency of wave III of brainstem auditory evoked responses in newborn piglets.
Key Words: Hyperbilirubinemia; Brainstem auditory evoked response; Piglet


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