Effect of Hyperbilirubinemia on the Brainstem Auditory Evoked Response in Newborn Piglets. |
Chang Won Choi, Jong Hee Hwang, Saem Kang, Jae Won Shim, So Hee Chung, Sun Young Koh, Yun Sil Chang, Won Soon Park |
1Department of Pediatrics, Samsung Seoul Hospital, College of Medicine, Sungkyunkwan University, Seoul, Korea. wspark@smc.samsung.co.kr 2Department of Pediatrics, Kangbuk Samsung Hospital, College of Medicine, Sungkyunkwan University, Seoul, Korea. 3Department of Pediatrics, Samsung Cheil Hospital, College of Medicine, Sungkyunkwan University, Seoul, Korea. |
신생자돈에서 고빌리루빈혈증이 뇌간청각유발반응에 미치는 영향에 대한 연구 |
, , , , , , , |
1 2 3 |
|
|
Abstract |
PURPOSE We sought to know the effect of hyperbilirubinemia on brainstem auditory evoked response in newborn piglets. METHODS To achieve the concentration of bilirubin above 20 mg/dL, we injected a bolus of 50 mg/kg of bilirubin intravenously over 30 minutes, followed by 30-40 mg/kg/ hr of bilirubin continuous intravenous infusion to 10 newborn piglets. Brainstem auditory evoked responses were obtained from these piglets at baseline, 1 hour, 2 hours, 3 hours and 4 hours after the exposure to hyperbilirubinemia. RESULTS: The mean amplitude of wave V was 0.33+/-0.03 microV at baseline, 0.32+/-0.04 microV at 1 hour, 0.33+/-0.05 microV at 2 hours, 0.23+/-0.04 microV at 3 hours and 0.26+/-0.05 microV at 4 hours of experiment and began to decrease after 3 hours of the exposure to hyperbilirubinemia. The latency of wave III was 4.06+/-0.08 ms at baseline, 3.95+/-0.09 ms at 1 hour, 4.05+/-0.10 ms at 2 hours, 4.05+/-0.09 ms at 3 hours, 4.12+/-0.11 ms at 4 hours of experiment and began to increase after 1 hour of the exposure to hyperbilirubinemia. CONCLUSION Hyperbilirubinemia decreased the amplitude of wave V and increased the latency of wave III of brainstem auditory evoked responses in newborn piglets. |
Key Words:
Hyperbilirubinemia; Brainstem auditory evoked response; Piglet |
|