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Journal of the Korean Society of Neonatology 2001;8(1):65-71.
Published online May 1, 2001.
Clinical Effects of Newfactan in the Treatment of Moderate to Severe Respiratory Distress Syndrome.
Seung Hee Ha, Yong Woon Baek
Department of Pediatrics, College of Medicine, Kosin University, Pusan, Korea.
중등도 이상의 신생아 호흡곤란 증후군에서의 Newfactan 보충요법의 임상효과
,
Abstract
PURPOSE
This study was designed to investigate the clinical effects of Newfactan in the treatment of moderate to severe respiratory distress syndrome.
METHODS
There were enrolled 20 preterm infants who were diagnosed as grade III or grade IV respiratory distress syndrome at Kosin University Gospel Hospital from July 1997 to May 2000. All of these preterm infants were treated for rescue. To investigate the improvement of respiratory parameters we used FiO2, MAP, a/APO2 ratio, OI.
RESULTS
Newfactan was administered to the patients at 7.2+/-7.4 hours (range 1.5- 32) after birth and 7 cases (35%) were administered one dose, 8 (40%) were administered two doses and 5 (25%) were administered three doses. The dose interval from first to second dose was 9.2+/-12.3 hours (range 5-46). The dose interval from second to third dose was 27.6+/-5.4 hours (range 21-35). The need of FiO2 showed decreased tendency especially between 4 to 6 hour after administration (P<0.05). PaCO2 and OI were decreased and a/APO2 ratio was increased after administration (P<0.05). MAP was not changed statistically (P>0.05). There were 41 complications and outcomes including PDA, sepsis, pneumothorax, intraventricular hemorrhage, BPD, ROP, and necrotizing enterocolitis.
CONCLUSION
The clinical effects of Newfactan in the treatment of grade III or grade IV respiratory distress syndrome were significant in improving FiO2, PaCO2, a/APO2 ratio and OI.
Key Words: Respiratory distress syndrome, Newfactan, Preterm infant


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