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Neonatal Med > Volume 18(2); 2011 > Article
Journal of the Korean Society of Neonatology 2011;18(2):365-369.
DOI: https://doi.org/10.5385/jksn.2011.18.2.365    Published online November 25, 2011.
Successful Opening of Ductus Arteriosus with Milrinone in a Newborn with Tetralogy of Fallot and Pulmonary Atresia.
Chong Bock Won, Min Young Kim, Duk Young Choi, Hye Jung Cho, So Yeon Shim, Dong Woo Son
Department of Pediatrics, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, Korea. sondw@gilhospital.com
Tetralogy of Fallot (TOF) assumes its' most severe form when accompanied by pulmonary atresia (PA). Preserving the patent ductus arteriosus to maintain pulmonary blood flow is life-saving for patients with this congenital heart disease. Milrinone, a selective phosphodiesterase III inhibitor, is a potent vasodilator. Here, we report the successful use of milrinone for a newborn infant with TOF and PA for keeping the ductus arteriosus open and thereby maintaining pulmonary circulation. Milrinone is a useful drug because of its inotropic, lusitropic, and pulmonary vasodilating effects, in addition to its ability to keep the ductus arteriosus open and its relatively mild side-effects. Case series and comparative studies will be needed in the future to verify the effectiveness of this drug.
Key Words: Congenital heart disease; Tetralogy of Fallot; Pulmonary atresia; Ductus arteriosus; Milrinone; Phosphodiesterase inhibitor; Newborn
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