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Neonatal Med > Volume 18(2); 2011 > Article
Journal of the Korean Society of Neonatology 2011;18(2):221-227.
DOI: https://doi.org/10.5385/jksn.2011.18.2.221    Published online November 25, 2011.
Identification of Characteristics and Risk Factors Associated with Mortality in Hydrops Fetalis.
Hoon Ko, Byong Sop Lee, Ki Soo Kim, Hye Sung Won, Pil Ryang Lee, Jae Yoon Shim, Ahm Kim, Ai rhan Kim
1Department of Pediatrics, Division of Neonatology, Asan Medical Center, Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea. arkim@amc.seoul.kr
2Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Abstract
PURPOSE
The objectives were to identify the characteristics of neonates with hydrops fetalis, and to identify the risk factors associated with mortality.
METHODS
A retrospective review of AMC (Asan Medical Center) dataset was performed from January 1990 to June 2009. The characteristics of 71 patients with hydrops fetalis were investigated and they were divided into two groups: the survived group and the expired group. Various perinatal and neonatal factors in two groups were compared to find out risk factors associated with mortality based on univariate analysis, followed by multiple regression analyses (SPSS version 18.0).
RESULTS
Of those 71 neonates (average gestational age: 33 weeks, birth weight: 2.6 kg), 38 survived, 33 died, resulting in overall mortality rate of 46.5%. The most common etiology was idiopathic followed by chylothorax, cardiac anomalies, twin-to-twin transfusion, meconium peritonitis, cardiac arrythmias, and congenital infections. Factors that were associated independently with mortality in logistic regression analyses were low 5-minutes Apgar score, hyaline membrane disease and delayed in achieving 50th percentile ideal body weight for appropriate gestational age by 10 days.
CONCLUSION
In this study, 5-minutes Apgar score, hyaline membrane disease and delayed in achieving 50th percentile ideal body weight for appropriate gestational age by 10 days were significant risk factors associated with mortality in hydrops fetalis. Therefore, the risk of death among neonates with hydrops fetalis depends on the illness immediately after birth and severity of hydrops fetalis. Informations from this study may prove useful in prediction of prognosis to neonates with hydrops fetalis.
Key Words: Hydrops fetalis, Mortality, Risk factor


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