Neonatal Med Search


Neonatal Med > Volume 22(3); 2015 > Article
Neonatal Medicine 2015;22(3):173-176.
DOI:    Published online August 31, 2015.
A Case of Lactobacillus Bacteremia during Probiotic Supplementation in a Very Preterm Infant with Short Bowel Syndrome.
Seon Nyo Kim, Hae Yun Lee, Saeyun Kim, Byung kook Lee, Young Hwa Jung, Joosun Huh, Jae Gu Seo, Seung Han Shin, Ee Kyung Kim, Han Suk Kim, Jung Hwan Choi
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
2R&D Center, Cell Biotech Co., Ltd., Gimpo, Korea.
Probiotics are living micro-organisms that beneficially affect the composition of the host intestinal microflora. In very preterm infants, probiotics reportedly help reduce necrotizing enterocolitis (NEC), invasive fugal colonization and sepsis, and enable the establishment of complete enteral feeding at an earlier stage. However, emerging evidence has indicated the risk of potential side effects of probiotic use, such as gut organism translocation, including probiotic organisms, in infants that are more premature. In the present report, we describe a case of Lactobacillus bacteremia in a very preterm infant with short bowel syndrome. Lactobacillus sepsis developed during the therapeutic use of this organism for diarrhea and diarrhea-related malabsorption. The organism isolated from the blood sample was found to be of the same strain as that administered, by using molecular techniques. The findings of the present case suggest that probiotics should be carefully used, particularly in very preterm infants with altered intestinal permeability such as short bowel syndrome.
Key Words: Probiotics; Lactobacillus; Very preterm infant; Short bowel syndrome; Bacteremia


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