Association of Interleukin-1alpha-889, beta-31, beta-511 Polymorphism with Risk of Bronchopulmonary Dysplasia.

Kang,  Jeong Hee; Lee,  Jung Jin; Cho,  Sung Il; Choi,  Youjin; Jo,  Heui Seung; Lee,  Kyu Hyung

doi:2013.20.4.413

Neonatal Med > Volume 20(4); 2013 > Article

Original Article

Neonatal Medicine 2013;20(4):413-421.
DOI: https://doi.org/10.5385/nm.2013.20.4.413 Published online January 15, 2014.

Association of Interleukin-1alpha-889, beta-31, beta-511 Polymorphism with Risk of Bronchopulmonary Dysplasia.

Jeong Hee Kang, Jung Jin Lee, Sung Il Cho, Youjin Choi, Heui Seung Jo, Kyu Hyung Lee

¹Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea. joneona@cha.ac.kr
²Graduate School of Public Health, Seoul National University, Seoul, Korea.

Abstract

PURPOSE
Although improvements in neonatal care techniques have increased the survival rate of preterm infants, bronchopulmonary dysplasia (BPD) remains an important factor in neonatal mortality and morbidity. BPD is a multifactorial disease associated with genetic and clinical risk factors related to lung development and perinatal inflammation. Interleukin-1 (IL-1) is a crucial cytokine in the early stages of inflammation. In the present study, we aimed to determine the association between the IL-1 polymorphisms, clinical risk factors, and BPD in preterm infants.
METHODS
The study was performed who consented infants born at less than 34 weeks' gestation. The alleles of the 3 sites of the IL-1 gene (IL-1alpha-889, IL-1beta-31, and IL-1beta-511) were determined using Taqman(R)-based allelic discrimination assays. Clinical data were reviewed from the medical records.
RESULTS
A total of 31 infants with BPD and 73 control infants were enrolled in the study. The gestational age (P=0.001) and birth weight (P=0.001) were lower in the BPD group compared to those in the control group. The incidence of respiratory distress syndrome (RDS; P=0.002), patent ductus arteriosus (P=0.01), and retinopathy of prematurity (P<0.001) was higher in the BPD group compared to that in the control group. The frequency of IL-1alpha-889TT was higher in the BPD group (6.5% vs. 0.0%, P=0.028) compared to that in the control group. The frequencies of IL-1alpha-889T, IL-1beta-31T, and IL-1beta-511T did not differ between the BPD and control groups. In logistic regression analysis, gestational age and RDS were found to be associated with BPD.
CONCLUSION
IL-1alpha-889, IL-1beta-31, and IL-1beta-511 polymorphisms are not associated with the development of BPD in preterm infants.

Key Words: Bronchopulmonary dysplasia; Polymorphism; Interleukin-1