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Neonatal Med > Volume 18(1); 2011 > Article
Journal of the Korean Society of Neonatology 2011;18(1):89-95.
DOI: https://doi.org/10.5385/jksn.2011.18.1.89    Published online May 15, 2011.
Hypernatremia and Intraventricular Hemorrhage in Very Low Birth Weight Infants (<1,250 g).
Soo Ho Lee, Cheol Hwan So, Seung Hoon Keum, Seung Taek Yoo, Doo Young Choi, Yeon Kyun Oh
Department of Pediatrics, Wonkwang University College of Medicine, Iksan, Korea. oyk5412@wonkwang.ac.kr
Hypernatremia most frequently occurs in the immature newborn and be severe in association with intraventricular hemorrhage (IVH). This study examined the frequency, onset and risk factors of hypernatremia, and the relationship between hypernatremia and IVH in very low birth weight (VLBW; <1,250 g) infants.
We retrospectively reviewed the medical records of 55 VLBW infants admitted between January 2006 and December 2009 to the neonatal intensive care unit of Wonkwang University Hospital and who survived over 7 days. Serum sodium concentration, sodium intake, fluid and weight loss, as suggested risk factors of hypernatremia, and the incidence of IVH were evaluated. The infants were divided into a hypernatremia group (> or =150 mEq/L) and nonhypernatremia group, and were compared.
Incidence of hypernatremia in the VLBW infants was 52.7%, and mean starting time of hypernatremia was 2.8+/-1.3 days. There were no differences in the sodium and fluid intake between the two groups. Weight loss at day 3 after birth was significantly higher in the hypernatremia compared to the nonhypernatremia group (P<0.05); thereafter weight loss was non-significantly higher. The incidence of IVH in VLBW infants was 38.2%, and the difference between the two groups was not significant.
Hypernatremia occurs commonly in VLBW infants and is most commonly caused by weight loss in the early days after birth. Incidence of IVH is not likely influenced by hypernatremia with marginally elevated sodium concentration.
Key Words: Hypernatremia, Intraventricular hemorrhage, Very low birth weight infants


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