Antimicrobial Management of Neonatal Sepsis.

Kim,  Ellen Ai Rhan

doi:2012.19.2.53

Neonatal Med > Volume 19(2); 2012 > Article

Review

Journal of the Korean Society of Neonatology 2012;19(2):53-64.
DOI: https://doi.org/10.5385/jksn.2012.19.2.53 Published online May 31, 2012.

Antimicrobial Management of Neonatal Sepsis.

Ellen Ai Rhan Kim

Division of Neonatology, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea. arkim@amc.seoul.kr

Abstract

Neonatal infections are frequent complications of neonates receiving intensive care unit. In particular, large cohort study has suggested that neonatal infections among extremely low birth weight infants are associated with poor neurodevelopmental and growth outcomes in early childhood. This review article will focus on the rational use of empirical antibiotics/antifungal therapy for early and late onset sepsis/fungemia, duration of antibiotic treatment, highlight clinically relevant aspects of the antibiotics commonly used in the treatment of sepsis, antibiotics requiring therapeutic dose monitoring, and management of antibiotic-resistant infection in the neonate.

Key Words: Neonate; Sepsis; Antibiotics; Therapeutic drug monitoring; Resistance