Optimal Ventilatory Strategies in Preterm Infants: Permissive Hypercapnia.

Hwang,  Jong Hee

doi:2014.21.2.114

Neonatal Med > Volume 21(2); 2014 > Article

Review

Neonatal Medicine 2014;21(2):114-121.
DOI: https://doi.org/10.5385/nm.2014.21.2.114 Published online May 30, 2014.

Optimal Ventilatory Strategies in Preterm Infants: Permissive Hypercapnia.

Jong Hee Hwang

Department of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. jonghee117@hanmail.net

Abstract

Bronchopulmonary dysplasia associated with lung injury is an important morbidity in extremely low birth weight infants. Lung injury during mechanical ventilation is associated with high tidal volume and high end-inspiratory lung volume. Lung injury and bronchopulmonary dysplasia may be prevented with ventilatory strategies using optimal gas exchange such as permissive hypercapnia. This article will review the pathophysiologic background of lung injury and the current therapeutic ventilatory strategies such as permissive hypercapnia to reduce lung injury in preterm infants.

Key Words: Pulmonary ventilation; Bronchopulmonary dysplasia; Hypercapnia; Infant; Newborn